tsh receptor การใช้

• These antibodies activate adenylate cyclase by binding to the TSH receptor.
• However, they may be involved in prolonging the TSH receptor halflife.
• Iodine deficiency is the most common cause of primary hypothyroidism and TSH receptor.
• Stimulating antibodies to the TSH receptor mimic TSH and cause Graves'disease.
• The mechanisms proposed for this side effect involve a TSH receptor common to both thyrocytes and retro-orbital tissue.
• In addition, hCG shows some cross-reactivity to the TSH receptor and therefore can stimulate production of thyroid hormones.
• Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present.
• Uncontrolled and inadequately treated maternal hyperthyroidism may also result in fetal and neonatal hyperthyroidism due to the transplacental transfer of stimulatory TSH receptor antibodies ( TRAbs ).
• TPO antibody is measured more easily than the TSH receptor antibody, and so is often used as a surrogate in the diagnosis of Graves'disease.
• Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.
• This is different from the thyroid condition called Grave s disease, as Grave s disease causes a hyper-function from external factors such as immunoglobulin that activate the TSH receptors.
• Patients present with hyperthyroidism and may be mistaken for Graves disease, if TSH receptor positive, or thyroiditis because of absent uptake on a thyroid radionuclide uptake scan due to suppression of thyroid function by exogenous thyroid hormones.
• Experimental evidence show that the mature receptor protein contains up to 17 leucine-rich repeats, each composed of 24 amino acids spanning the extracellular domain flanked by the cysteine-rich Asn 208 ) aligns with that on the sixth repeat of gonadotropin and TSH receptors.